Preparation of Magnetic Fluorescent Dual-drug Nanocomposites for Codelivery of Kaempferol and Paclitaxel
来源期刊：Journal Of Wuhan University Of Technology Materials Science Edition2018年第1期
论文作者：张小娟 PAN Qingqing 郝凌云 LIN Qing TIAN Xiangping ZHANG Zhiying WANG Shanshan WANG Hehe
文章页码：256 - 262
摘 要：Magnetic fluorescent dual-drug nanocomposites（MFDDs） were developed with the aim of simultaneouly delivering two different anticancer drugs, kaempferol（KAE） and paclitaxel（PTX）. Firstly, Fe3O4/bovine serum albumin（Fe3O4/BSA） composite microspheres with physically entrapped KAE were prepared, then microspheres were modified with PTX/graphene quantum dots（PTX/GQDs） through chemically bonding, and the MFDDs were obtained. The properties of nancomposites were characterized by X-ray diffractometry, Fourier-transform infrared spectroscopy, transmission electron microscopy, vibrating sample magnetometry and X-ray fluorescence spectrometry. It was found that the superparamagnetic nanocomposites had ultrafine size（below 110 nm）, high saturation magnetization of 24.36 emu/g, and significant fluorescence. Furthermore, the cumulative in vitro release of the MFDDs exhibited controlled drug release. Cell viability experiments confirmed that the co-administration of KAE with PTX had a superior cytotoxicity to the Hela cells compared with single drug-loaded forms. Therefore, dual anticancer drug-loaded MFDDs have the potential to be used for cancer combined chemotherapy.
张小娟1，PAN Qingqing2，郝凌云1，LIN Qing1，TIAN Xiangping1，ZHANG Zhiying1，WANG Shanshan3，WANG Hehe1
1. School of Material Engineering, Jinling Institute of Technology2. College of Chemical Engineering, Nanjing Forestry University3. Laboratory Animal Center, Nanjing University of Chinese Medicine
摘 要：Magnetic fluorescent dual-drug nanocomposites（MFDDs） were developed with the aim of simultaneouly delivering two different anticancer drugs, kaempferol（KAE） and paclitaxel（PTX）. Firstly, Fe3O4/bovine serum albumin（Fe3O4/BSA） composite microspheres with physically entrapped KAE were prepared, then microspheres were modified with PTX/graphene quantum dots（PTX/GQDs） through chemically bonding, and the MFDDs were obtained. The properties of nancomposites were characterized by X-ray diffractometry, Fourier-transform infrared spectroscopy, transmission electron microscopy, vibrating sample magnetometry and X-ray fluorescence spectrometry. It was found that the superparamagnetic nanocomposites had ultrafine size（below 110 nm）, high saturation magnetization of 24.36 emu/g, and significant fluorescence. Furthermore, the cumulative in vitro release of the MFDDs exhibited controlled drug release. Cell viability experiments confirmed that the co-administration of KAE with PTX had a superior cytotoxicity to the Hela cells compared with single drug-loaded forms. Therefore, dual anticancer drug-loaded MFDDs have the potential to be used for cancer combined chemotherapy.
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