Influence of Samarium on Learning and Memory Function of Rats
来源期刊：Journal of Rare Earths2006年第S1期
论文作者：施维林 申秀英 马锡英
文章页码：419 - 422
摘 要：<正>Sixty-four Spraque-Dawley （SD） big rats with weaning weight of （195 qqqqqq 15） g were randomly divided into 4 groups with 8 males and 8 females each group. One group drunk with de-ionized water served as control and was also used for analysis of the background. The other three groups rats were raised by de-ionized water containing low, middle and high concentrations of Sm for four months, then learning and memory tests were carried out in Y-electric maze. Compared with the control rats, the learning and memory of rats in low and middle groups shows a deterioration trend, exhibiting the function degradation of rats’ brain. It may results from the rare earth elements through blood-brain barrier affecting the normal physiological functions of rats’ brain. In addition, the activity of superoxide dismutase （SOD） in rals’ brain tie-creases , while the content of malondialdehyde （MDA.） concentration increases. The decreased SOD activity and the increased MDA mean the degeneration the ability of anti-oxidation in rats’ brain, which are accordance with the degradation of learning and memory function of rats in low and middle Sm groups.
施维林，申秀英，马锡英
摘 要：<正>Sixty-four Spraque-Dawley （SD） big rats with weaning weight of （195 qqqqqq 15） g were randomly divided into 4 groups with 8 males and 8 females each group. One group drunk with de-ionized water served as control and was also used for analysis of the background. The other three groups rats were raised by de-ionized water containing low, middle and high concentrations of Sm for four months, then learning and memory tests were carried out in Y-electric maze. Compared with the control rats, the learning and memory of rats in low and middle groups shows a deterioration trend, exhibiting the function degradation of rats’ brain. It may results from the rare earth elements through blood-brain barrier affecting the normal physiological functions of rats’ brain. In addition, the activity of superoxide dismutase （SOD） in rals’ brain tie-creases , while the content of malondialdehyde （MDA.） concentration increases. The decreased SOD activity and the increased MDA mean the degeneration the ability of anti-oxidation in rats’ brain, which are accordance with the degradation of learning and memory function of rats in low and middle Sm groups.
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