Synthesis,characterization and antitumor activity of rare earth（Y,La） substituted phosphotungstates containing 5-fluorouracil
来源期刊：Journal of Rare Earths2012年第6期
论文作者：刘霞 甘强 冯长根
文章页码：604 - 608
摘 要：Two rare earth substituted Keggin-type phosphotungstates containing 5-fluorouracil,K10C4H4FN2O2Y（PW11O39）2·10H2O（FYPW） and K9（C4H4FN2O2）2La（PW11O39）2·18H2O（FLaPW）were synthesized in aqueous solution,and the structures were characterized by Fourier transform infrared spectroscopy（FT-IR）,element analysis,inductively coupled plasma spectrometry（ICP）,X-ray powder diffraction（XRD） and 1 H nuclear magnetic resonance（NMR）.Thermal analysis showed that the decomposition processes of the two compounds could be divided into three steps,the loss of crystal water,the decomposition of 5-fluorouracil unit and the decomposition of Keggin-type polyanions. The in vitro cytotoxicities against HEK 293,HeLa and HepG-2 cells were studied by methyl thiazolyl tetrazolium（MTT）assay.The results showed that FYPW and FLaPW had higher antitumor activities than 5-fluorouracil,C4H4FN2O2H2PW12O40·8H2O and rare earth substituted polyoxometalates K11Ln（PW11O39）2·nH2O（Ln=Y,La）.It was concluded that introducing 5-fluorouracil and rare earth（Y or La）into its structure was a considerable way to enhance antitumor activities of polyoxometalates.
刘霞1，甘强2，冯长根2
1. College of Science,China Agricultural University2. School of Mechatronical Engineering,Beijing Institute of Technology
摘 要：Two rare earth substituted Keggin-type phosphotungstates containing 5-fluorouracil,K10C4H4FN2O2Y（PW11O39）2·10H2O（FYPW） and K9（C4H4FN2O2）2La（PW11O39）2·18H2O（FLaPW）were synthesized in aqueous solution,and the structures were characterized by Fourier transform infrared spectroscopy（FT-IR）,element analysis,inductively coupled plasma spectrometry（ICP）,X-ray powder diffraction（XRD） and 1 H nuclear magnetic resonance（NMR）.Thermal analysis showed that the decomposition processes of the two compounds could be divided into three steps,the loss of crystal water,the decomposition of 5-fluorouracil unit and the decomposition of Keggin-type polyanions. The in vitro cytotoxicities against HEK 293,HeLa and HepG-2 cells were studied by methyl thiazolyl tetrazolium（MTT）assay.The results showed that FYPW and FLaPW had higher antitumor activities than 5-fluorouracil,C4H4FN2O2H2PW12O40·8H2O and rare earth substituted polyoxometalates K11Ln（PW11O39）2·nH2O（Ln=Y,La）.It was concluded that introducing 5-fluorouracil and rare earth（Y or La）into its structure was a considerable way to enhance antitumor activities of polyoxometalates.
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