Synthesis, Characterization and Antitumor Activity of Lanthanum(Ⅲ) Complex with Demethylcantharidate
来源期刊：JOURNAL OF RARE EARTHS2005年第5期
论文作者：Xu Ling Wang Xu Li Rongchang Zou Jiajia Yin Fuling
Key words：lanthanum complex; demethylcantharidate group; antitumor activity; rare earths;
Abstract: A novel complex of lanthanum(Ⅲ) with demethylcantharidate group (DCA), Na[La(DCA)2(H2O)], was synthesized in aqueous solution and characterized by elemental analysis, molar conductance, IR, UV, 1H-NMR spectra and TG-DTA. The results suggest that lanthanum ion is seven-coordinated. Six oxygen atoms are from carboxyl groups and cyclic ethers of two DCA ligand, and on oxygen is from a H2O. The antitumor activities of the complex against HL-60 human leukemia, BGC-823 human gastric carcinoma, Bel-7402 human hepatic carcinoma, Hela human cervical carcinoma were investigated with MTT or SRB assays. Na[La(DCA)2(H2O)] exhibits stronger inhibition against certain kinds of cancer cells than Na2DCA in vitro.
Xu Ling1，Wang Xu1，Li Rongchang1，Zou Jiajia1，Yin Fuling1
(1.Department of Chemical Biology, School of Pharmaceutical Science, Peking University, Beijing 100083, China)
Abstract:A novel complex of lanthanum(Ⅲ) with demethylcantharidate group (DCA), Na[La(DCA)2(H2O)], was synthesized in aqueous solution and characterized by elemental analysis, molar conductance, IR, UV, 1H-NMR spectra and TG-DTA. The results suggest that lanthanum ion is seven-coordinated. Six oxygen atoms are from carboxyl groups and cyclic ethers of two DCA ligand, and on oxygen is from a H2O. The antitumor activities of the complex against HL-60 human leukemia, BGC-823 human gastric carcinoma, Bel-7402 human hepatic carcinoma, Hela human cervical carcinoma were investigated with MTT or SRB assays. Na[La(DCA)2(H2O)] exhibits stronger inhibition against certain kinds of cancer cells than Na2DCA in vitro.
Key words:lanthanum complex; demethylcantharidate group; antitumor activity; rare earths;
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