Synthesis, characterization and bioactivity evaluation of diallyl disulfide
来源期刊：中南大学学报(英文版)2006年第5期
论文作者：袁新科 陈晓青 蒋新宇 聂亚丽
文章页码：515 - 518
Key words：diallyl disulfide; microwave irradiation; phase transfer catalyst; bioactivity
Abstract: Diallyl disulfide was synthesized by phase transfer catalyst (PTC) during microwave irradiation. The effects of different factors, such as the power of microwave irradiation, the time of microwave irradiation, PTC reagents amount and the mole ratio of reactants, on the yield of product were investigated. The structure of diallyl disulfide was characterized by infrared spectra, mass spectra and 1H nuclear magnetic resonance. The bioactivity of diallyl disulfide was evaluated by cell viability assay on HepG2 hepatoma cells. The results show that the optimal reaction conditions are as follows: tetrabutylammonium bromide(TBAB) selected as a PTC, the mass ratio of TBAB to sodium disulfide of 0.021∶1, the power of irradiation of 195 W, the reaction time of 12 min, and the mole ratio of sodium disulfide to allyl chloride of 0.65∶1. The yield of diallyl disulfide is 82.2%. The synthetical diallyl disulfide appears to be cytotoxic to HepG2 hepatoma cells in a dose-dependent manner.
