Preparation and Evaluation of Dual Targeting Nanoparticles for Oral Cancer

吴珊珊¹，XIONG Fuliang¹，ZHANG Xueqiong¹，QIU Tong²，TANG Mingxiu¹，YE Xiaojing³，陈芷筠⁴，周刚⁵

1. Department of Phamaceutical Engineering, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology2. Biomedical Materials and Engineering Center, Wuhan University of Technology3. The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University4. Department of stomatology, Maternal and Child Health Hospital of Hubei Province5. Department of Oral Medicine, School and Hospital of Stomatology, Wuhan University

摘 要：A dual-receptor targeting delivery system based on acid-cleavage hydrazone bond was developed in the study. The characters of CMCS-hyd-CUR-EGFR-mAb were identified. The in vitro release studies revealed that this drug delivery system was acid-sensitive, and the self-assembled nanoparticles which were spherical. The in vitro results indicated that the dual-receptor targeting nanoparticles could be faster internalized into the Cal-27 cells via receptor-mediated endocytosis, which exhibited better antitumor activity than the one-receptor nanoparticles. The experimental results clearly reveal that CMCS-hyd-CUR-EGFR mAb provides a novel way for drug delivery in oral cancer treatment.

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