In vitro Degradation of Pure Mg for Esophageal Stent in Artificial Saliva
来源期刊：JOURNAL OF MATERIALS SCIENCE TECHNOLOG2016年第5期
论文作者：Rong-Chang Zeng Xiao-Ting Li Li-Jun Liu Shuo-Qi Li Fen Zhang
文章页码：437 - 444
摘 要：Magnesium and its alloys as biodegradable implant materials can be potentially used in cardiovascular and orthopedic devices.However,few studies have focused on its application in esophageal stents.In this paper,time-lapse degradation characteristics of pure Mg were analyzed by scanning electron microscopy,energy dispersive spectroscopy,X-ray diffraction,Fourier transform infrared spectroscopy,hydrogen evolution,pH and electrochemical measurements after immersion in arti?cial saliva for different times.Results revealed that a dense degradation product?lm formed on samples,which mainly consisted of two kinds of layers:one was calcium phosphate compounds with different structures;the other was thin magnesium hydrate layer close to the substrate.Less pH increase and low degradation rate were observed in the?rst 5 days of immersion,which can be ascribed to the formation of a thicker and denser layer on the sample surface with increasing immersion time.And then there was an increase in degradation rate and pH values;the deposition layer remained almost intact after immersion for 6 and 8 days.After 10 days of immersion,the degradation rate and pH value remained stable,and the calcium phosphate layer was delaminated and the inner magnesium hydrate layer was exposed.This study indicated that pure Mg exhibited desirable degradation resistance in arti?cial saliva,which provided magnesiumbased materials with the potential to be used as esophageal stents.
Rong-Chang Zeng1,2，Xiao-Ting Li1,2，Li-Jun Liu1,2，Shuo-Qi Li1,2，Fen Zhang1,2
1. College of Materials Science and Engineering, Shandong University of Science and Technology2. State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and the Ministry of Science and Technology, Shandong University of Science and Technology
摘 要：Magnesium and its alloys as biodegradable implant materials can be potentially used in cardiovascular and orthopedic devices.However,few studies have focused on its application in esophageal stents.In this paper,time-lapse degradation characteristics of pure Mg were analyzed by scanning electron microscopy,energy dispersive spectroscopy,X-ray diffraction,Fourier transform infrared spectroscopy,hydrogen evolution,pH and electrochemical measurements after immersion in arti?cial saliva for different times.Results revealed that a dense degradation product?lm formed on samples,which mainly consisted of two kinds of layers:one was calcium phosphate compounds with different structures;the other was thin magnesium hydrate layer close to the substrate.Less pH increase and low degradation rate were observed in the?rst 5 days of immersion,which can be ascribed to the formation of a thicker and denser layer on the sample surface with increasing immersion time.And then there was an increase in degradation rate and pH values;the deposition layer remained almost intact after immersion for 6 and 8 days.After 10 days of immersion,the degradation rate and pH value remained stable,and the calcium phosphate layer was delaminated and the inner magnesium hydrate layer was exposed.This study indicated that pure Mg exhibited desirable degradation resistance in arti?cial saliva,which provided magnesiumbased materials with the potential to be used as esophageal stents.
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