Synthesis, spectral, optical and anti-inflammatory activity of complexes derived from 2-aminobenzohydrazide with some rare earths
来源期刊：JOURNAL OF RARE EARTHS2015年第7期
论文作者：Nasser Mohammed Hosny El Sayed A.El Morsy Yousery E.Sherif
文章页码：758 - 764
摘 要：Three new metal complexes derived from Er（III）, Dy（III） and Zr（IV） with 2-aminobenzohydrazide（ABH） were synthesized and characterized by elemental analyses, IR, 1H-NMR, ES-MS and transmission electron microscopy（TEM）. The morphology and the particle size were determined by TEM. The results showed that the ligand acted as neutral bi-dentate coordinating to the metal ions through the carbonyl oxygen and amidic amino nitrogen. The aromatic amine group remained inert towards coordination. The optical band gap was measured and found to be 3.3, 3.5 and 4.3 e V for Er（III）, Dy（III） and Zr（IV）, respectively. The optical band gap values indicated a semi-conducting nature of the investigated complexes. The anti-inflammatory and analgesic activities of the tested compounds were determined and compared with standard meloxicam.
Nasser Mohammed Hosny1，El Sayed A.El Morsy2,3，Yousery E.Sherif2,4
1. Chemistry Department, Faculty of Science, Port-Said University2. Clinical Pharmacology Department, Faculty of Medicine, Mansoura University3. Pharmacology and Therapeutics Department, Qassim College of Medicine, Qassim University4. Department of Chemistry, Faculty of Science and Arts, Taibah University
摘 要：Three new metal complexes derived from Er（III）, Dy（III） and Zr（IV） with 2-aminobenzohydrazide（ABH） were synthesized and characterized by elemental analyses, IR, 1H-NMR, ES-MS and transmission electron microscopy（TEM）. The morphology and the particle size were determined by TEM. The results showed that the ligand acted as neutral bi-dentate coordinating to the metal ions through the carbonyl oxygen and amidic amino nitrogen. The aromatic amine group remained inert towards coordination. The optical band gap was measured and found to be 3.3, 3.5 and 4.3 e V for Er（III）, Dy（III） and Zr（IV）, respectively. The optical band gap values indicated a semi-conducting nature of the investigated complexes. The anti-inflammatory and analgesic activities of the tested compounds were determined and compared with standard meloxicam.
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