Enhanced Healing of Full-thickness Diabetic Wounds Using Bioactive Glass and Yunnan Baiyao Ointments
来源期刊:Journal Of Wuhan University Of Technology Materials Science Edition2014年第5期
论文作者:毛葱 LIN Cai 陈晓峰
文章页码:1063 - 1070
摘 要:In order to accelerate the chronic wounds healing, we investigated the healing effects of bioactive glass and Yunnan baiyao ointments in streptozotocin-induced diabetic rats. The ointments were prepared by mixing 45S5 bioactive glass powder(16% weight) with Vaseline and different weight percentages of Yunnan baiyao. Full-thickness defect wounds were created on the back of 130 SD rats and were randomly divided into 8 groups. The wound healing rates were calculated at 4, 7, 10, 14 and 21 days after surgery. The samples were harvested for further observations. Considering the wound closure rate, group 6(with 5% Yunnan baiyao) has better wound healing performance than other diabetic groups. The lower infl ammatory response was observed by gross observation and confirmed by the results of H&E staining and TEM observation. Besides, the proliferation of fibroblasts, the formation of granulation tissue, as well as the vascularization, were improved in group 6 compared to other diabetic groups. All results suggest that bioactive glass and Yunnan baiyao ointments can accelerate the recovery of diabetes-impaired skin wounds, and comparing to other diabetic groups, group 6(with 5% Yunnan baiyao) has better healing effect.
毛葱1,2,LIN Cai1,2,3,陈晓峰1,2
2. The School of Materials Science and Engineering, South China University of Technology
摘 要:In order to accelerate the chronic wounds healing, we investigated the healing effects of bioactive glass and Yunnan baiyao ointments in streptozotocin-induced diabetic rats. The ointments were prepared by mixing 45S5 bioactive glass powder(16% weight) with Vaseline and different weight percentages of Yunnan baiyao. Full-thickness defect wounds were created on the back of 130 SD rats and were randomly divided into 8 groups. The wound healing rates were calculated at 4, 7, 10, 14 and 21 days after surgery. The samples were harvested for further observations. Considering the wound closure rate, group 6(with 5% Yunnan baiyao) has better wound healing performance than other diabetic groups. The lower infl ammatory response was observed by gross observation and confirmed by the results of H&E staining and TEM observation. Besides, the proliferation of fibroblasts, the formation of granulation tissue, as well as the vascularization, were improved in group 6 compared to other diabetic groups. All results suggest that bioactive glass and Yunnan baiyao ointments can accelerate the recovery of diabetes-impaired skin wounds, and comparing to other diabetic groups, group 6(with 5% Yunnan baiyao) has better healing effect.
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