Synthesis of bifunctional Gd2O3:Eu3+ nanocrystals and their applications in biomedical imaging
来源期刊：Journal of Rare Earths2015年第5期
论文作者：吴燕利 徐贤柱 李倩兰 阳如春 丁海新 肖强
文章页码：529 - 534
摘 要：Ultrafine Gd2O3:Eu3+ nanocrystals were successfully prepared by a simple reverse microemulsion method and subsequent calcination. Their structural, optical and magnetic properties were investigated using scanning electron microscopy（SEM）, transmission electron microscopy（TEM）, X-ray diffraction（XRD）, Fourier transform infrared（FTIR）, photoluminescence（PL）, and magnetic property measurement system（MPMS）. The amorphous Gd2（CO3）3:Eu3+ colloidal spheres were proved as an intermediate product, and gradually transformed into crystallized Gd2O3:Eu3+ with average diameter less than 100 nm. The paramagnetic property of the synthesized Gd2O3:Eu3+ nanocrystals were confirmed with its linear hysteresis plot（M-H）. And Gd2O3:Eu3+ nanocrystals showed high contrast T1-enhancing modality due to the presence of the Gd3+ ions onto the particle surface. In addition, the application of the Gd2O3:Eu3+ nanocrystals as biotag for cell labeling was reported, red fluorescence from Eu3+ ions observed by fluorescence microscopy showed that the nanocrystals could permeate the cell membrane. Cytotoxicity studies of the Gd2O3:Eu3+ nanocrystals showed no adverse effect on cell viability, evidencing their high biological compatibility. Therefore, the nanoprobe formed from Gd2O3:Eu3+ nanocrystals provided the dual modality of optical and magnetic resonance imaging.
吴燕利1，徐贤柱2，李倩兰1，阳如春1，丁海新1，肖强1
1. Jiangxi Key Laboratory of Organic Chemistry Jiangxi Science and Technology Normal University2. College of Life Science Jiangxi Normal University
摘 要：Ultrafine Gd2O3:Eu3+ nanocrystals were successfully prepared by a simple reverse microemulsion method and subsequent calcination. Their structural, optical and magnetic properties were investigated using scanning electron microscopy（SEM）, transmission electron microscopy（TEM）, X-ray diffraction（XRD）, Fourier transform infrared（FTIR）, photoluminescence（PL）, and magnetic property measurement system（MPMS）. The amorphous Gd2（CO3）3:Eu3+ colloidal spheres were proved as an intermediate product, and gradually transformed into crystallized Gd2O3:Eu3+ with average diameter less than 100 nm. The paramagnetic property of the synthesized Gd2O3:Eu3+ nanocrystals were confirmed with its linear hysteresis plot（M-H）. And Gd2O3:Eu3+ nanocrystals showed high contrast T1-enhancing modality due to the presence of the Gd3+ ions onto the particle surface. In addition, the application of the Gd2O3:Eu3+ nanocrystals as biotag for cell labeling was reported, red fluorescence from Eu3+ ions observed by fluorescence microscopy showed that the nanocrystals could permeate the cell membrane. Cytotoxicity studies of the Gd2O3:Eu3+ nanocrystals showed no adverse effect on cell viability, evidencing their high biological compatibility. Therefore, the nanoprobe formed from Gd2O3:Eu3+ nanocrystals provided the dual modality of optical and magnetic resonance imaging.
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