N-terminal pro-B-type natriuretic peptide as prognostic marker for patients of non ST-segment elevation myocardial infarction

SHON Ho Sun¹, HWANG Kyung Kuk², BAE Jang Whan², KIM Kyung Ah³, LEE Jong Yun⁴, RYU Keun Ho¹

(1. Database and Bioinformatics Laboratory, School of Electrical & Computer Engineering, also,
PSM of School of Medicine, Chungbuk National University, Cheongju, Chungbuk 361-763, Korea;
2. Department of Medicine, School of Medicine, Chungbuk National University, Cheongju,
Chungbuk 361-763, Korea;
3. Department of Biomedical Engineering, School of Medicine, Chungbuk National University, Cheongju,
Chungbuk 361-763, Korea;
4. Department of Informatics and Convergence, Chungbuk National University Cheongju, Chungbuk 361-763, Korea)

Abstract:In this work, we analyzed only the patients of the NSTEMI (non ST-segment elevation myocardial infarction) who arrived at the hospital within 12 h after symptoms started. Using NSTEMI follow-up data within, the characteristics of the clinical data, the risk factor, and the blood tested in the hospital visit were analyzed for MACE (major adverse cardiac events) patients. MACE includes cardiac death, MI (myocardial infarction), Re-PCI, and CABG (coronary artery bypass graft). As a result, from the NSTEMI patients which can be followed up for over 12 m, NT-ProBNP (p=0.014) and age (p=0.045) are found to be the independent risk factors related to MACE. Accordingly, they can be useful for the diagnosis and prognosis for NSTEMI patients as a biomarker.

Key words:non ST-segment elevation myocardial infarction; NT-ProBNP; cardiovascular disease