Enantioselective extraction of mandelic acid enantiomers based on chiral ligand exchange^①

来源期刊：中南大学学报(英文版)2005年第2期

论文作者：唐课文 黄可龙

文章页码：123 - 128

Key words：ligand exchange; extraction; chiral separation; mandelic acid enantiomers

Abstract: Based on the chiral ligand exchange, the distribution behavior of mandelic acid enantiomers, and the partition of Cu²⁺at different pH values were studied in a water/alcohol two-phase system containing Cu²⁺and N^- n^-dodecyl-L-proline(A). The influences of the solvent sort, the pH value, the concentrations of Cu²⁺and chiral ligand on the partition coefficient(K) and separation factor(α) were discussed. The experimental results show that the A formed has more stable ternary complex withD-mandelic acid enantiomer than withL-mandelic acid enantiomer.There is an important influence of the pH value onKandα. When the pH values are less than 3.5, the formation of binary complexes is thermodynamically unfavourable.Kandαbecome maximum when pH values are above 3.5 and the molar ratio of the chiral ligand to Cu²⁺ is 2∶1.

基金信息：the National Natural Science Foundation of China