Synthesis of calixarenes and their extraction performance for ester catechins

来源期刊：中南大学学报(英文版)2007年第6期

论文作者：易健民 黄赛金 唐课文 黄可龙

文章页码：798 - 798

Key words：calixarene; synthesis; ester catechin monomer; extraction

Abstract: A series of extractants (tert-butylcalix[6]arene, tert-butylcalix[8]arene and octeacetate of tert-butylcalix[8]arene) were synthesized, and their structures were identified by IR and ¹H-NMR. The distribution behavior of ester catechins monomer in the aqueous and chloroform two-phase system containing one of calixarene was studied. The influences of different extractants, concentration of tert-butylcalix[8]arene and extraction temperature on the partition coefficients and the separation factors were investigated. The experiment results show that tert-butylcalix[8]arene is the best extractant that forms a more stable supramolecular compound with gallocatechin gallate (GCG) than with epigallocathechin gallate (EGCG) or epicatechin gallate (ECG). When the concentration of p-tert-butylcalix[8]arene is 3.79 mmol/L, the extraction temperature is 4 ℃, the partition coefficients of K_GCG, K_ECG, K_EGCG are 0.987, 0.629, 0.449，the separation factors of α₁ and α₂ are 1.450 and 1.596, respectively. The important factors influencing the extraction properties of calixarene are discovered to be its cavity size and hydrogen bonding.

基金信息：the National Natural Science Foundation of China